Publications | Hilde Schjerven Lab

Selected Publications

Podgorica M, Drivet E, Vestbøstad J, Kvam AK, Wik HS, Munthe L, Schjerven H. Azaindole 1, a selective Rock1/2 kinase inhibitor, induces G2/M arrest and cell death in B-cell acute lymphoblastic leukemia (B-ALL). Leuk Lymphoma. 2025 Jul 29:1-5. doi: 10.1080/10428194.2025.2536125. Epub ahead of print. PMID: 40728071.

Podgorica M, Drivet E, Viken JK, Richman A, Vestbøstad J, Szodoray P, Kvam AK, Wik HS, Tjønnfjord GE, Munthe LA, Frietze S, Schjerven H. Transcriptome analysis of primary adult B-cell lineage acute lymphoblastic leukemia identifies pathogenic variants and gene fusions, and predicts subtypes for in depth molecular diagnosis. Eur J Haematol. 2024 May;112(5):731-742. doi: 10.1111/ejh.14164. Epub 2024 Jan 8. PMID: 38192186; PMCID: PMC10990798.

Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR. Ikaros is a principal regulator of Aire⁺ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance. Sci Immunol. 2023 Oct 27;8(88):eabq3109. doi: 10.1126/sciimmunol.abq3109. Epub 2023 Oct 27. PMID: 37889983;

PMCID: PMC11433069.

Cosgun KN, Jumaa H, Robinson ME, Kistner KM, Xu L, Xiao G, Chan LN, Lee J, Kume K, Leveille E, Fonseca-Arce D, Khanduja D, Ng HL, Feldhahn N, Song J, Chan WC, Chen J, Taketo MM, Kothari S, Davids MS, Schjerven H, Jellusova J, Müschen M. Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies. bioRxiv [Preprint]. 2023 Mar 15:2023.03.13.532152. doi: 10.1101/2023.03.13.532152. PMID: 36993619; PMCID: PMC10054980.

Kogut S, Paculova H, Rodriguez P, Boyd J, Richman A, Palaria A, Schjerven H, Frietze S. Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia. Epigenomes. 2022 Oct 19;6(4):37. doi: 10.3390/epigenomes6040037. PMID: 36278683; PMCID: PMC9624360.

ssvQC: An integrated CUT&RUN quality control workflow for histone modifications and transcription factors”. Boyd J, Rodriguez P, Schjerven H, and Frietze S. BMC Res Notes. 2021 Sep 20;14(1):366. doi: 10.1186/s13104-021-05781-8. PMID: 34544495

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia”. Rodriguez PD, Paculova H, Kogut S, Heath J, Schjerven H, Frietze S. Int J Mol Sci. 2021 Mar 7;22(5):2683. doi: 10.3390/ijms22052683. PMID: 33799946

International Journal of Molecular Sciences

"Stromal cell protein kinaseC-Beta inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance."

E. Park, J. Chen, A. Moore, M. Mangolini, A. Santoro, J. R. Boyd, H. Schjerven, V. Ecker, M. Buchner, J. C. Williamson, P. J. Lehner, L. Gasparoli, O. Williams, J. Bloehdorn, S. Stilgenbauer, M. Leitges, A. Egle, M. Schmidt-Supprian, S. Frietze, I. Ringshausen. Sci Transl Med. 2020 Jan 15;12(526). pii: eaax9340. doi: 10.1126/scitranslmed.aax9340. PMID: 31941829

A kindred with Mutant IKAROS and autoimmunity.
Van Nieuwenhove E, Garcia-Perez JE, Helsen C, Rodriguez PD, van Schouwenburg PA, Dooley J, Schlenner S, van der Burg M, Verhoeyen E, Gijsbers R, Frietze S, Schjerven H, Meyts I, Claessens F, Humblet-Baron S, Wouters C, Liston A. J Allergy Clin Immunol. 2018 Apr 27. pii: S0091-6749(18)30618-3. doi: 10.1016/j.jaci.2018.04.008, PMID: 29705243

The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.

Ye J, Qiu J, Bostick JW, Ueda A, Schjerven H, Li S, Jobin C, Chen ZE, Zhou L. Cell Reports, 2017 Nov 21;21(8):2277-2290. PMID: 29166616

Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.

Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA. Nat Immunol. 2017 Jun;18(6):694-704.

Metabolic gatekeeper function of B-lymphoid transcription factors.
Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H,

Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Nature. 2017 Feb 23;542(7642):479-483

Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL.
*Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M. J Exp Med. 2017 Mar 6;214(3):793-814. doi: 10.1084/jem.20160049. PMID: 28190001 * Corresponding author.

Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.
Arenzana, TL, Schjerven H, and Smale ST. Genes & Development, 2015 Sep 1;29(17):1801-16. doi: 10.1101/gad.266999.115. PMID: 26314708

Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.
Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. Nat Commun. 2015; 6:6471. PMID: 25753524. PMCID: PMC4366523

"Restriction of IL-22-Producing T Cell Responses and Differential Regulation of Regulatory T Cell Compartments by Zinc Finger Transcription Factor Ikaros".
Heller JJ, *Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, *Zhou L. J Immunol. 2014 Oct 15;193(8):3934-46. PMID: 25194055 * Co-corresponding authors.

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros.
Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. Nat Immunol. 2013 Oct;14(10):1073-83. PMID: 24013668

Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros.

Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. Nat Immunol. 2008 Aug; 9(8):927-36. PMID: 18568028

For a complete list through PubMed:
http://www.ncbi.nlm.nih.gov/pubmed/?term=Schjerven+h[au ]