Hilde Schjerven, PhD

Associate Professor
Laboratory Medicine

Member, UCSF Bakar ImmunoX

Member, UCSF Helen Diller Family Comprehensive Cancer Center (Hematopoietic Malignancies Program)

Member, UCSF Precision Medicine in Rheumatology (PREMIER) Center

Member, UCSF BMS graduate program

Publications: 

Transcriptome analysis of primary adult B-cell lineage acute lymphoblastic leukemia identifies pathogenic variants and gene fusions, and predicts subtypes for in depth molecular diagnosis.

European journal of haematology

Podgorica M, Drivet E, Viken JK, Richman A, Vestbøstad J, Szodoray P, Kvam AK, Wik HS, Tjønnfjord GE, Munthe LA, Frietze S, Schjerven H

Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies.

Blood

Kadriye Nehir Cosgun, Mark E Robinson, Salim Oulghazi, Liang Xu, Gang Xiao, Lai N Chan, Jaewoong Lee, Kohei Kume, Etienne Leveille, David Fonseca Arce, Dhruv Khanduja, Niklas Feldhahn, Joo Y. Song, Wing C. Chan, Jianjun Chen, M. Mark Taketo, Hilde Schjerven, Julia Jellusova, Shalin Kothari, Matthew S Davids, Markus Müschen

Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.

Science immunology

Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR

ß-catenin engages IKZF factors to control lymphopoiesis.

The Journal of Immunology

Kadriye Nehir Cosgun, Huda Jumaa, Mark E. Robinson, Liang Xu, Gang Xiao, David Fonseca Arce, Dhruv Khanduja, Lai N. Chan, Jaewoong Lee, Hilde Schjerven, Julia Jellusova, Markus Müschen

Targeted engagement of �-catenin-Ikaros complexes in refractory B-cell malignancies.

bioRxiv : the preprint server for biology

Cosgun KN, Jumaa H, Robinson ME, Kistner KM, Xu L, Xiao G, Chan LN, Lee J, Kume K, Leveille E, Fonseca-Arce D, Khanduja D, Ng HL, Feldhahn N, Song J, Chan WC, Chen J, Taketo MM, Kothari S, Davids MS, Schjerven H, Jellusova J, M?schen M

Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia

Epigenomes

Kogut S, Paculova H, Rodriguez P, Boyd J, Richman A, Palaria A, *Schjerven H, *Frietze S.

Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia.

Epigenomes

Kogut S, Paculova H, Rodriguez P, Boyd J, Richman A, Palaria A, Schjerven H, Frietze S

Individual zinc finger domains of Ikaros have specific roles in regulating murine myeloid hematopoietic development.

The Journal of Immunology

Johanne Vestbostad, Mirjam Podgorica, Matthew Strege, Douglas Pinheiro, Ludvig Munthe, Hilde Schjerven

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

(Review, Submitted 2021). Available as Preprint

Rodriguez PD, Paculova H, Kogut S, Heath J, Schjerven H, Frietze S.

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia.

International journal of molecular sciences

Abstract PO-62: Overcoming venetoclax resistance in B-cell malignancies by antagonism of stromal TGF-beta-mediated drug resistance.

Blood Cancer Discovery

Eugene Park, Jingyu Chen, Andrew Moore, Maurizio Mangolini, Joseph R. Byod, Hilde Schjerven, James C. Williamson, Paul J. Lehner, Michael Leitges, Alexander Egle, Marc Schmidt-Supprian, Seth Frietze, Ingo Ringshausen

Ikaros regulates gene expression programs required for proper BCR-activation in mature B cells.

The Journal of Immunology

Princess D Rodriguez, William Howell, Joseph Boyd, Seth Frietze, Hilde Schjerven

Stromal cell protein kinase C-ß inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.

Science translational medicine

Park E, Chen J, Moore A, Mangolini M, Santoro A, Boyd JR, Schjerven H, Ecker V, Buchner M, Williamson JC, Lehner PJ, Gasparoli L, Williams O, Bloehdorn J, Stilgenbauer S, Leitges M, Egle A, Schmidt-Supprian M, Frietze S, Ringshausen I

Ikaros mutations can bypass the requirement for second co-stimulatory signal and lead to break of B-cell tolerance.

The Journal of Immunology

Hilde Schjerven, Princess D Rodriguez, William Howell, Johanne Vestbostad, Seth Frietze, Hilde Schjerven

Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development.

The Journal of experimental medicine

Fistonich C, Zehentmeier S, Bednarski JJ, Miao R, Schjerven H, Sleckman BP, Pereira JP

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors.

Nature

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M

Ikaros regulates B-cell tolerance.

The Journal of Immunology

Hilde Schjerven, Princess Rodriguez, Danielle Hagen, Marit Rasmussen, Etapong F. Ayongaba, Seth Frietze

Ikaros regulates epigenetic and transcriptional programs in progenitor B cell leukemia.

The Journal of Immunology

Hilde Schjerven, Etapong F. Ayongaba, Princess Rodriguez, Seth Frietze

A kindred with mutant IKAROS and autoimmunity.

The Journal of allergy and clinical immunology

Van Nieuwenhove E, Garcia-Perez JE, Helsen C, Rodriguez PD, van Schouwenburg PA, Dooley J, Schlenner S, van der Burg M, Verhoeyen E, Gijsbers R, Frietze S, Schjerven H, Meyts I, Claessens F, Humblet-Baron S, Wouters C, Liston A

The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.

Cell reports

Ye J, Qiu J, Bostick JW, Ueda A, Schjerven H, Li S, Jobin C, Chen ZE, Zhou L

Abstract 93: Transcriptional control of glucocorticoid responses in leukemia.

Experimental and Molecular Therapeutics

Lai N. Chan, Zhengshan Chen, Gang Xiao, Jae Woong Lee, Kadriye Nehir Cosgun, Huimin Geng, Valeria Cazzaniga, Hilde Schjerven, Ross A. Dickins, Markus Muschen

Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.

Nature immunology

Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA

Metabolic gatekeeper function of B-lymphoid transcription factors.

Nature

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M

Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL.

The Journal of experimental medicine

Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M

Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway.

Immunity

Li S, Heller JJ, Bostick JW, Lee A, Schjerven H, Kastner P, Chan S, Chen ZE, Zhou L

Analysis of Ikaros tumor suppressor function in BCR-ABL1+ pre-B ALL reveals conserved target genes and biological pathways.

The Journal of Immunology

Hilde Schjerven, Etapong Fonabei Ayongaba, Jami McLaughlin, Donghui Cheng, Linn Margrethe Eggesbø, Ida Lindeman, Eugene Park, Owen N Witte, Stephen T Smale, Seth Frietze, Markus Muschen

Role of the transcription factor Ikaros in development of autoimmune disease.

The Journal of Immunology

Hilde Schjerven, Seth Frietze, Si-Han Hai, Michelle Hermiston, Scott Kogan, Markus Muschen

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.

Blood

Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S

Ikaros tumor suppressor function in pre-B ALL: potential role of Ikaros target gene Ctnnd1 (IRM10P.621).

The Journal of Immunology

Hilde Schjerven, Linn Eggesbo, Ida Lindeman, Markus Muschen

STAT5 antagonism of B cell superenhancer networks initiates progenitor B cell leukemia and predicts patient survival (HEM1P.222).

The Journal of Immunology

Michael Farrar, Casey Katerndahl, Lynn Heltemes Harris, Mark Willette, christine Henzler, Rendong Yang, Kevin Silverstein, Seth Frietze, Hilde Schjerven, Laura Ramsey, Gregory Hubbard, Markus Muschen, Steven Kornblau

Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.

Nature communications

Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M

Erk and Stat5 Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia.

Blood

Shojaee Seyedmehdi, Zhengshan Chen, Maike Buchner, Christian Hurtz, Huimin Geng, Hilde Schjerven, Lai N Chan, Phillip Koeffler, Cheryl L. Willman, Stephen Hunger, Sinisa Dovat, Elisabeth Paietta, Wolf-Karsten Hofmann, Ari M Melnick, Warren S. Alexander, Steven M. Kornblau, Markus Muschen

PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells.

Blood

Seyedmehdi Shojaee, Valeria Cazzaniga, Hilde Schjerven, Maike Buchner, Christian Hurtz, Huimin Geng, Andreas Hochhaus, Giovanni Cazzaniga, Ari M Melnick, Steven M. Kornblau, Thomas G Graeber, Markus Muschen

Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros.

Journal of immunology (Baltimore, Md. : 1950)

Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, Zhou L

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros.

Nature immunology

Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST

118 Modulation of Treg and Th17 fate decision by selective ikaros zinc fingers.

Cytokine

Jennifer Heller, Hilde Schjerven, Ju Qiu, Aileen Lee, Stephen Smale, Liang Zhou

Selective requirement of Ikaros zinc fingers in Treg and Th17 fate decision. (P1137).

The Journal of Immunology

Jennifer Heller, Hilde Schjerven, Ju Qiu, Aileen Lee, Stephen Smale, Liang Zhou

Role of Ikaros in hematopoiesis and tumor suppression: Selective functions of individual zinc fingers within the DNA-binding domain of Ikaros. (42.3).

The Journal of Immunology

Hilde Schjerven, Seth Frietze, Jami McLaughlin, Donghui Cheng, Peggy Farnham, Owen Witte, Stephen Smale

Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros.

Nature immunology

Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H

Regulation of B cell fate specification and VH gene rearrangements by Ikaros.

The FASEB Journal

Damien REYNAUD, Karen REDDY, Hilde SCHJERVEN, Chauncey SPOONER, Eric BERTOLINO, Stephen T SMALE, Susan WINANDY, Harinder SINGH

Regulation of the Mucosal IgA System.

Mucosal Immune Defense: Immunoglobulin A

Finn-Eirik Johansen, Ranveig Braathen, Else Munthe, Hilde Schjerven, Per Brandtzaeg

Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses.

Journal of immunology (Baltimore, Md. : 1950)

Schneeman TA, Bruno ME, Schjerven H, Johansen FE, Chady L, Kaetzel CS

De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor.

Journal of immunology (Baltimore, Md. : 1950)

Schjerven H, Tran TN, Brandtzaeg P, Johansen FE

Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytes.

The British journal of dermatology

Mørk G, Schjerven H, Mangschau L, Søyland E, Brandtzaeg P

Regulation of the Formation and External Transport of Secretory Immunoglobulins.

Critical Reviews in Immunology

F.-E. Johansen, H. Schjerven, I. N. Norderhaug, P. Brandtzaeg

Regulation of the formation and external transport of secretory immunoglobulins.

Critical Reviews in Immunology

Norderhaug IN, Johansen FE, Schjerven H, Brandtzaeg P

E2F-mediated growth regulation requires transcription factor cooperation.

The Journal of biological chemistry

van Ginkel PR, Hsiao KM, Schjerven H, Farnham PJ