
Associate Professor
M_Laboratory Medicine
Member, UCSF Bakar ImmunoX
Member, UCSF Helen Diller Family Comprehensive Cancer Center (Hematopoietic Malignancies Program)
Member, UCSF Precision Medicine in Rheumatology (PREMIER) Center
Member, UCSF BMS graduate program
Publications
Transcriptome analysis of primary adult B-cell lineage acute lymphoblastic leukemia identifies pathogenic variants and gene fusions, and predicts subtypes for in depth molecular diagnosis.
European journal of haematology
Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
Science immunology
ß-catenin engages IKZF factors to control lymphopoiesis.
The Journal of Immunology
Targeted engagement of �-catenin-Ikaros complexes in refractory B-cell malignancies.
bioRxiv : the preprint server for biology
ssvQC: an integrated CUT&RUN quality control workflow for histone modifications and transcription factors.
BMC research notes
Individual zinc finger domains of Ikaros have specific roles in regulating murine myeloid hematopoietic development.
The Journal of Immunology
Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia
(Review, Submitted 2021). Available as Preprint
Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia.
International journal of molecular sciences
Abstract PO-62: Overcoming venetoclax resistance in B-cell malignancies by antagonism of stromal TGF-beta-mediated drug resistance.
Blood Cancer Discovery
Ikaros regulates gene expression programs required for proper BCR-activation in mature B cells.
The Journal of Immunology
Azaindole 1, a selective Rock1/2 kinase inhibitor, induces G2/M arrest and cell death in B-cell acute lymphoblastic leukemia (B-ALL).
Science translational medicine
Ikaros mutations can bypass the requirement for second co-stimulatory signal and lead to break of B-cell tolerance.
The Journal of Immunology
Ikaros regulates chromatin landscape in mature B cells, and is critical for B cell tolerance.
The Journal of Immunology
Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development.
The Journal of experimental medicine
Ikaros establishes an epigenetic program required for proper two-signal activation of naive B cells.
The Journal of Immunology
Ikaros regulates B-cell tolerance.
The Journal of Immunology
Ikaros regulates epigenetic and transcriptional programs in progenitor B cell leukemia.
The Journal of Immunology
A kindred with mutant IKAROS and autoimmunity.
The Journal of allergy and clinical immunology
The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.
Cell reports
Abstract 93: Transcriptional control of glucocorticoid responses in leukemia.
Experimental and Molecular Therapeutics
Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.
Nature immunology
Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL.
The Journal of experimental medicine
Analysis of Ikaros tumor suppressor function in BCR-ABL1+ pre-B ALL reveals conserved target genes and biological pathways.
The Journal of Immunology
Role of the transcription factor Ikaros in development of autoimmune disease.
The Journal of Immunology
Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.
Genes & development
Ikaros tumor suppressor function in pre-B ALL: potential role of Ikaros target gene Ctnnd1 (IRM10P.621).
The Journal of Immunology
STAT5 antagonism of B cell superenhancer networks initiates progenitor B cell leukemia and predicts patient survival (HEM1P.222).
The Journal of Immunology
Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.
Nature communications
Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros.
Journal of immunology (Baltimore, Md. : 1950)
Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros.
Nature immunology
Selective requirement of Ikaros zinc fingers in Treg and Th17 fate decision. (P1137).
The Journal of Immunology
Role of Ikaros in hematopoiesis and tumor suppression: Selective functions of individual zinc fingers within the DNA-binding domain of Ikaros. (42.3).
The Journal of Immunology
Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros.
Nature immunology
Regulation of the Mucosal IgA System.
Mucosal Immune Defense: Immunoglobulin A
Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950)
De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor.
Journal of immunology (Baltimore, Md. : 1950)
Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytes.
The British journal of dermatology
Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4.
Journal of immunology (Baltimore, Md. : 1950)
A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor.
Journal of immunology (Baltimore, Md. : 1950)
Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional response.
Journal of immunology (Baltimore, Md. : 1950)
Mannuronan C-5-epimerases and their application for in vitro and in vivo design of new alginates useful in biotechnology.
Metabolic engineering
Regulation of the Formation and External Transport of Secretory Immunoglobulins.
Critical Reviews in Immunology
Regulation of the formation and external transport of secretory immunoglobulins.
Critical Reviews in Immunology
E2F-mediated growth regulation requires transcription factor cooperation.
The Journal of biological chemistry