Hilde Schjerven, PhD

Associate Professor
Laboratory Medicine

Member, UCSF Bakar ImmunoX

Member, UCSF Helen Diller Family Comprehensive Cancer Center (Hematopoietic Malignancies Program)

Member, UCSF Precision Medicine in Rheumatology (PREMIER) Center

Member, UCSF BMS graduate program

Publications: 

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia

(Review, Submitted 2021). Available as Preprint

Rodriguez PD, Paculova H, Kogut S, Heath J, Schjerven H, Frietze S.

Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia.

International journal of molecular sciences

Stromal cell protein kinase C-ß inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance.

Science translational medicine

Park E, Chen J, Moore A, Mangolini M, Santoro A, Boyd JR, Schjerven H, Ecker V, Buchner M, Williamson JC, Lehner PJ, Gasparoli L, Williams O, Bloehdorn J, Stilgenbauer S, Leitges M, Egle A, Schmidt-Supprian M, Frietze S, Ringshausen I

Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development.

The Journal of experimental medicine

Fistonich C, Zehentmeier S, Bednarski JJ, Miao R, Schjerven H, Sleckman BP, Pereira JP

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors.

Nature

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M

A kindred with mutant IKAROS and autoimmunity.

The Journal of allergy and clinical immunology

Van Nieuwenhove E, Garcia-Perez JE, Helsen C, Rodriguez PD, van Schouwenburg PA, Dooley J, Schlenner S, van der Burg M, Verhoeyen E, Gijsbers R, Frietze S, Schjerven H, Meyts I, Claessens F, Humblet-Baron S, Wouters C, Liston A

The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.

Cell reports

Ye J, Qiu J, Bostick JW, Ueda A, Schjerven H, Li S, Jobin C, Chen ZE, Zhou L

Abstract 93: Transcriptional control of glucocorticoid responses in leukemia.

Experimental and Molecular Therapeutics

Lai N. Chan, Zhengshan Chen, Gang Xiao, Jae Woong Lee, Kadriye Nehir Cosgun, Huimin Geng, Valeria Cazzaniga, Hilde Schjerven, Ross A. Dickins, Markus Muschen

Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.

Nature immunology

Katerndahl CDS, Heltemes-Harris LM, Willette MJL, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KAT, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA

Metabolic gatekeeper function of B-lymphoid transcription factors.

Nature

Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M

Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1+ pre-B ALL.

The Journal of experimental medicine

Schjerven H, Ayongaba EF, Aghajanirefah A, McLaughlin J, Cheng D, Geng H, Boyd JR, Eggesbø LM, Lindeman I, Heath JL, Park E, Witte ON, Smale ST, Frietze S, Müschen M

Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway.

Immunity

Li S, Heller JJ, Bostick JW, Lee A, Schjerven H, Kastner P, Chan S, Chen ZE, Zhou L

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.

Blood

Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S

Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.

Nature communications

Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M

Erk and Stat5 Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia.

Blood

Shojaee Seyedmehdi, Zhengshan Chen, Maike Buchner, Christian Hurtz, Huimin Geng, Hilde Schjerven, Lai N Chan, Phillip Koeffler, Cheryl L. Willman, Stephen Hunger, Sinisa Dovat, Elisabeth Paietta, Wolf-Karsten Hofmann, Ari M Melnick, Warren S. Alexander, Steven M. Kornblau, Markus Muschen

PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells.

Blood

Seyedmehdi Shojaee, Valeria Cazzaniga, Hilde Schjerven, Maike Buchner, Christian Hurtz, Huimin Geng, Andreas Hochhaus, Giovanni Cazzaniga, Ari M Melnick, Steven M. Kornblau, Thomas G Graeber, Markus Muschen

Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros.

Journal of immunology (Baltimore, Md. : 1950)

Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, Zhou L

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros.

Nature immunology

Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST

118 Modulation of Treg and Th17 fate decision by selective ikaros zinc fingers.

Cytokine

Jennifer Heller, Hilde Schjerven, Ju Qiu, Aileen Lee, Stephen Smale, Liang Zhou

Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros.

Nature immunology

Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H

Regulation of B cell fate specification and VH gene rearrangements by Ikaros.

The FASEB Journal

Damien REYNAUD, Karen REDDY, Hilde SCHJERVEN, Chauncey SPOONER, Eric BERTOLINO, Stephen T SMALE, Susan WINANDY, Harinder SINGH

Regulation of the Mucosal IgA System.

Mucosal Immune Defense: Immunoglobulin A

Finn-Eirik Johansen, Ranveig Braathen, Else Munthe, Hilde Schjerven, Per Brandtzaeg

Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses.

Journal of immunology (Baltimore, Md. : 1950)

Schneeman TA, Bruno ME, Schjerven H, Johansen FE, Chady L, Kaetzel CS

De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor.

Journal of immunology (Baltimore, Md. : 1950)

Schjerven H, Tran TN, Brandtzaeg P, Johansen FE

Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytes.

The British journal of dermatology

Mørk G, Schjerven H, Mangschau L, Søyland E, Brandtzaeg P

Regulation of the Formation and External Transport of Secretory Immunoglobulins.

Critical Reviews in Immunology

F.-E. Johansen, H. Schjerven, I. N. Norderhaug, P. Brandtzaeg

Regulation of the formation and external transport of secretory immunoglobulins.

Critical Reviews in Immunology

Norderhaug IN, Johansen FE, Schjerven H, Brandtzaeg P

E2F-mediated growth regulation requires transcription factor cooperation.

The Journal of biological chemistry

van Ginkel PR, Hsiao KM, Schjerven H, Farnham PJ